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Acne Onex Cream (Benzoyl Peroxide / Clindamycin / Niacinamide) 5/1/2% 30mL


This product is another general cream similar to Acne Treatment Cream. However, it switches out the Vitamin C for Niacinamide (Vitamin B3) which is more suitable for sensitive skin.

Vitamin C is an effective skin care ingredient, but it can irritate sensitive skin. If you’ve tried Vitamin C before and had a bad reaction, or if you know your skin responds poorly to strong ingredients, this cream may be better suited for you.

Vitamin C and Niacinamide are also not recommended for use together, so you may prefer this cream if you know Niacinamide works better for your particular skin texture, acne, and skin care needs.

Benzoyl Peroxide

Benzoyl peroxide is a topical acne product. Benzoyl peroxide exhibits antibacterial activity. It also has drying actions, sebostatic effects, and causes mild skin desquamation. Benzoyl peroxide improves both inflammatory and non-inflammatory acne lesions. Benzoyl peroxide is effective as monotherapy in mild cases of acne and is used as an adjuvant in moderate to severe cases of acne. A study 1 in the United Kingdom showed that an OTC 5% benzoyl peroxide topical formulation (Panoxyl Aquagel) was as effective as topical benzoyl peroxide/erythromycin combination and the oral tetracyclines minocycline and oxytetracycline for treatment of mild to moderate acne. Topical benzoyl peroxide and benzoyl peroxide/erythromycin combinations were not associated with propionibacterial antibiotic resistance which occurs with the tetracyclines. Benzoyl peroxide has also been used in the off-label treatment of decubitus ulcers. Benzoyl peroxide is available as prescription and non-prescription products and is available in combination with erythromycin, hydrocortisone, and sulfur (see separate monographs for each of the combination products). The FDA has revised labeling requirements for all non-prescription (over-the-counter) topical acne products, including benzoyl peroxide, to ensure consistency with the standardized 'Drug Facts' formatting. Benzoyl peroxide is a generally recognized as safe and effective (GRASE) active ingredient in over-the-counter topical acne drug products.

Clindamycin Phosphate

Clindamycin is an antibiotic structurally similar to lincomycin, from which it is derived. Clindamycin traditionally has been considered an effective anti-anaerobic antibiotic, but it recently has been shown to be effective in combination with pyrimethamine in treating toxoplasmic encephalitis in patients with AIDS 2. Clindamycin was approved by the FDA in 1970 and is marketed as the hydrochloride salt for oral administration and as the phosphate salt for parenteral, topical or vaginal administration. The FDA approved a single-dose vaginal cream (Clindesse™) for bacterial vaginosis in November 2004. The FDA approved Evoclin™, an aerosol topical foam containing 1% clindamycin, for the treatment of acne vulgaris in December 2004


Niacin (nicotinic acid or 3-pyridinecarboxylic acid) is a B-complex vitamin. Good dietary sources of niacin are animal proteins, beans, green vegetables, liver, mushrooms, peanuts, whole wheat, and unpolished rice. Niacin is also present in cereal grains but is largely bound to plant proteins, and thus is poorly absorbed after ingestion. Niacin is one of the substances used in the enrichment of refined flour, and our dietary intake of pre-formed niacin comes primarily from enriched grains. However, the body's niacin requirement is also met by the biosynthesis of niacin from tryptophan, an amino acid. For example, milk and eggs do not contain niacin, but do contain large amounts of tryptophan from which niacin is derived. Each 60 mg of excess tryptophan (after protein synthesis) is converted to approximately 1 mg of niacin. Synthesis of the vitamin from tryptophan in proteins supplies roughly half the niacin requirement in man. Iron-deficiency or inadequate pyridoxine or riboflavin status will decrease the conversion of tryptophan to niacin and may contribute to deficiency, due to an interdependence of coenzymes in the niacin production pathway. A late and serious manifestation of niacin deficiency is pellagra, a clinical symptom complex principally affecting the GI tract, skin, and CNS, producing symptoms of diarrhea, dermatitis, and dementia, respectively. Pellagra may result from a niacin- and protein-deficient diet, isoniazid therapy, or certain diseases that result in poor utilization of tryptophan. Pellagra was the only vitamin-deficiency disease to ever reach epidemic proportions in the US; pellagra is rare today in industrialized countries due to the enrichment of refined flours.

Several synonyms for niacin and niacinamide exist. Synthetic niacin could be produced by the oxidation of nicotine, and the term 'nicotinic acid' evolved. Scientists also coined the terms 'nicotinamide' and 'niacinamide' for the amide form of nicotinic acid. The term 'niacin' has been used generically since the 1940's to label foods and to avoid association of the vitamins with the nicotine alkaloid from tobacco. Thus the name 'niacin' has been used to denote both chemical forms, which are equivalent as vitamins on a weight basis. Both nicotinic acid and nicotinamide are synthesized for inclusion in nutritional supplements. However, since nicotinic acid and nicotinamide have different pharmacologic properties outside of their use as vitamins, it is important to distinguish between the two forms in pharmaceutical products.

In clinical medicine, nicotinic acid is used as an antilipemic, but nicotinamide (niacinamide) is not effective for this purpose. Nicotinic acid was the first hypolipidemic agent shown to decrease the incidence of secondary myocardial infarction (MI) and reduce total mortality in MI patients. However, no incremental benefit of coadministration of extended-release niacin with lovastatin or simvastatin on cardiovascular morbidity and mortality over and above that demonstrated for extended-release niacin, simvastatin, or lovastatin monotherapy has been established. In addition, the AIM-HIGH trial demonstrated that the concurrent use of extended-release niacin (1500—2000 mg/day PO) and simvastatin does not result in a greater reduction in the incidence of cardiovascular events than simvastatin alone.3 These results are consistent with those of the larger HPS2-THRIVE trial in which the addition of extended-release niacin to effective statin-based therapy did not result in a greater reduction in the incidence of cardiovascular events. Furthermore, there was an increased risk of serious adverse events including an increased incidence of disturbances in diabetes control and diabetes diagnoses, as well as serious gastrointestinal, musculoskeletal, dermatological, infectious, and bleeding adverse events. There was also a statistically insignificant 9% proportional increase in the incidence of death from any cause in the niacin group.4 The ARBITER 6-HALTS trial demonstrated that the addition of extended-release niacin 2000 mg/day to statins results in significant regression in atherosclerosis as measured by carotid intima-media thickness, and is superior to the combination of ezetimibe and a statin.5 In an MRI study, the addition of extended-release niacin 2000 mg/day to statin therapy resulted in a significant reduction in carotid wall area compared to placebo.6 However, the NIA Plaque study, which was presented at the American Heart Association (AHA) 2009 Scientific Sessions, did not find a significant reduction in the progression of atherosclerosis associated with the addition of niacin to statin therapy as compared to statin monotherapy. Additionally, nicotinic acid has been used as a therapy for tinnitus, but efficacy data are scant. Some sustained-release nicotinic acid formulations have a lower incidence of flushing but a higher incidence of hepatotoxicity when compared to immediate-release forms.7 Some dosage forms are available without prescription. The FDA officially approved niacin in 1938.

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