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Bi-Estrogen/Progesterone Cream, 30mL


Any strength

Bi-Estrogen troches contain a combination of 80% Estriol and 20% Estradiol. Estriol and Estradiol are two of three principal estrogens produced by the body (the third being Estrone). Estradiol is substantially more active than its metabolites at the cellular level and when combined with Estriol can help improve menopausal symptoms such as hot flashes, vaginal dryness, burning/irritation; as well as assist in the prevention of osteoporosis. Estriol may also help improve cardiovascular risk factors and can reduce pro-carcinogenic effects of Estradiol. Progesterone is a naturally occurring progestin; commonly prescribed in combination with estrogen-containing medications in postmenopausal women with a uterus to help reduce the risk of developing cancer of the uterus, as well as prevent abnormal thickening of the uterine lining in women taking estrogen. It is also used to regulate menstrual periods in women who are pre-menopausal but have stopped having periods due to low progesterone levels.

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Patient Instructions

Applying Topical Hormone Cream: Bi-est/Progesterone cream

-First, wash your hands with soap and water

How to Apply: Bi-est/Progesterone cream should be applied once per day in the evening unless otherwise instructed by your physician.  Anytime up until the hour of bedtime is a good time. Anytime up until the hour of bedtime is a good time to apply.

Where to Apply

  • Bi-est/Progesterone cream may be applied vaginally, or to your inner thighs, calf, or abdomen  

    **Please note:   In order to prevent breast sensitivity and pain, do not apply estrogen anywhere on or near the breast.  We advise to not apply estrogens to the chest area and neck.   

Always Remember

  • * Limit your contact with other people or animals for 30min after applying hormone cream.  It is possible to transfer transdermal hormones to others if it is not fully absorbed.
  • * Wash hands immediately after applying hormone cream
  • * Do not mix or layer over other hormone creams or skin lotions
  • * Do not bathe or shower for 40min after applying cream
  • * Do not exercise or promote sweating for 2 hours after application
  • * Always be sure to follow the directions provided by your pharmacy and physician.


Please contact our medical office if you have any questions: 813-445-7342

Topical Hormones: Gels and Creams

Topical hormones come in a variety of dispensing devices. The most common devices include a pump, large syringe, Topi-Click, and single dose packets. When dispensing your hormone gel/cream it is important to understand how much you are supposed to apply.  


Here is a breakdown of how standard dispensing devices measure:

Pump:                  4 pumps = 1 ml

Topi-Click:          4 clicks = 1 ml

Syringe:               Syringes are typically measured in increments so you can measure the amount you dispense by pushing the plunger 1ml. Syringes designed to dispense topical hormones do not require a needle, the cream is dispensed through a nipple at the bottom of the syringe. The syringe plunger is pushed down to dispense the cream in measured doses. Syringes typically have lines marking 1ml measurements and come in various sizes to accommodate dosage amounts. If you need assistance reading the measurements on the syringe contact Defy Medical.

How to convert your hormone strength from % to milligrams.  

Sometimes pharmacists prefer to note the strength of the hormone cream in percentages rather than milligrams (mg). For example, it may be written on the label: Testosterone 10% gel 30ML. This is simply a different way of writing the strength. Here is how it works:  


To convert the % into milligrams simply move the decimal to the right one time.  


5% = 50 mg  

10% = 100 mg  

20% = 200 mg  


Using testosterone 10% gel 30 ML as an example, we can interpret this to mean “testosterone 100 milligrams (mg) per milliliter (ml). There are 30 ml in the order which means you have thirty 100 mg doses. If you are prescribed to “apply ½ ml every day” this means you are applying 50 mg and your 30 ml supply will last 60 days. Remember, the cream is 100 mg per ml and you are applying ½ ml (50 mg). Contact Defy Medical staff if you need clarification on your dosage instructions. 



Store your topical hormones at room temperature. Keep in the original closed container in a dark, cool, and dry place away from children. Discard unneeded medicine. 

Be sure to follow the dosage prescribed by your doctor located on the medication label.  

Topi-Click®  Dispensing Instructions 

 Read all information and instructions carefully before dispensing from the Topi-Click™.  

  1. Pop off the cover by placing thumb in groove on the front where it says REFILL and press upward on the cover’s thumb tab.  

  1. Turn the base slowly as shown below in Fig. 2 to dispense the specified _____ # of clicks per topical provider’s instructions. You may refer to the bottom for reminder instructions. 

  1. Apply by rubbing applicator pad to area of skin as directed by topical provider.  

  1. Replace cover firmly and tightly.    

  1. When the bottom line (see Fig. 5 below) reaches the engraved line above the word “Refill,” it may be time to call in for any refills because there are approximately 12 clicks left.  


The Refill Indicator: There are approximately (depending on viscosities) the following numbers of clicks left when the very bottom of the topical elevator reaches the line engravings on the front; Refer to Fig. 5 below. Look at the top front for these engravings:  


______ = 12 clicks left (first line from the top)     ______ = 32 clicks left (second line from the top)   


Downloadable at

The Topi-Click is a one-time use container and is not refillable.

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