Tri-Mix injectable (lyophilized), 5mL
Standard Formula: Papaverine 30 mg/Phentolamine 1 mg/Prostaglandin 10 mcg/mL
Tri-Mix is a self-administered penile injection, typically considered as part of the most powerful class of anti-erectile dysfunction agents. This contains three drugs from complementary classes mixed into a sterile injection and are designed to work synergistically (Papaverine, Phentolamine, and Alprostadil). Papaverine is a vasodilator, which causes blood vessels to expand and helps produce an erection by allowing the increase of blood flow to the penis. Phentolamine induces an erection when injected into the penis by relaxing and dilating blood vessels, along with elevating cardiac output. Prostaglandin E1 (Alprostadil) is a potent hormone-like substance that induces an erection by relaxing blood vessels in the penis and dilating cavernosal arteries. This dilation of the cavernosal arteries is accompanied by increased arterial inflow velocity, along with increased venous outflow resistance; which allows for more blood to flow into the penis and less blood to flow out of the penis. Bacteriostatic water and mixing syringe provided. Needles and syringes for injection are ordered separately.
Tri-Mix injectable, 5mL
This medication is used to treat certain causes of Erectile Dysfunction. It should begin to
Do not use the medication if it:
Do Not Use This Medication If You Have:
Priapism is an involuntary erection which lasts more than 4 hours and is unrelieved by ejaculation. This condition is a true urological emergency and early treatment allows the best chance for functional recovery.
How to prevent priapism when taking Tri-Mix or other penile injection therapies (ICP):
If you experience priapism, or an erection lasting longer than 2 hours:
If you experience priapism, or an erection lasting longer than 3 hours:
If you experience priapism, or an erection lasting longer than 4 hours:
If these do not work and erection has been present for 4hrs and/or is exquisitely painful then immediately visit the ER for treatment.
Tri-Mix- Papaverine HCl 150 mg/mL, Phentolamine Mesylate 5 mg/mL Prostaglandin E1 50 mcg/mL. 5 mL Vial. Lyophilized.
(prescription may also be written as Tri-Mix- Papaverine HCl 30 mg/mL, Phentolamine Mesylate 1 mg/mL, Prostaglandin E1 10 mcg/mL. 5 mL Vial).
Each bottle of Tri-Mix will arrive lyophilized (in powder form) and will need to be reconstituted (mixed) with a separate solution (diluent).The diluent is Bacteriostatic Water for Injection, USP. This is sterile water containing 0.9% Benzyl Alcohol added as an antimicrobial preservative. Refrigerate or freeze after reconstitution according to the storage instructions below.
Before you begin: Gather the materials you will need on a clean flat surface. Wash hands with soap and water and then dry.
Step 1: Remove the caps from the Tri-Mix injectable vial of powder and bacteriostatic water vial. Wipe the tops with the alcohol swabs and let dry.
Note: if using a 3ml/cc mixing syringe steps 2 - 6 will need to be completed 2 times (in 2mL and 3mL increments) to transfer all the fluid into the powder.
Step 2: Using the mixing syringe tighten the needle to the hub then pull hack the plunger to bring in 5 mL/cc of air.
Step 3: Push the plunger in to add 5 mL of air to the vial and then draw out 5 mL of bacteriostatic water by slowly pulling the plunger back out.
Step 4: Remove the needle from the bacteriostatic water vial and insert it into the Tri-Mix injectable vial of powder.
Step 5: Push the plunger to release the 5 mL of bacteriostatic water into the Tri-Mix injectable vial of powder.
Step 6: Draw out the same volume of air that you've injected (5 mL) from the Tri-Mix injectable medication vial before pulling the needle out. This will keep the pressure equal within the vial. Gently swirl (do not shake) the Tri-Mix injectable vial around until the solution is clear.
Step 7: Discard the remaining bacteriostatic water and store the Tri-Mix injectable vial acording to the storage directions below.
***Remember: Alternate the side of the penis and vary the injection site with each use.
You can purchase a Sharps Container, a hard-plastic container made for used syringes and needles, at your local pharmacy. If you did not purchase this container with your medication, you can use a hard-plastic container with a screw-on top such as a clothing softener or hard plastic detergent bottle. Be sure you can put both the syringe and the needle into the container easily. Whatever container you choose, be sure needles cannot break through the sides, bottom or top. Call your primary care physician or your local pharmacy to find out what your state or local requirements are for disposing of used syringes and needles.
Once mixed, keep Tri-Mix in the refrigerator and it will last 3 months. Storing in the freezer will extend the life of the medication to 6 months. If you store this medication in the freezer, you will need to take the vial out of the freezer and let it thaw completely out on the counter. You should not see any ice in the vial before using. Prior to being mixed, Tri-Mix powder can be kept at room temperature although it is good habit to store unmixed Tri-Mix in the refrigerator. If Tri-Mix is left out of the fridge for more than 3 days after being mixed, discard the vial.