Cyanocobalamin (Commercial) 1mg/ml, 10ml vial
Cyanocobalamin (vitamin B12) injection is a sterile, prescription-only parenteral formulation of a water-soluble cobalamin analogue that serves as the principal therapeutic option when oral absorption of the vitamin is impaired or when rapid repletion is clinically required.
Cyanocobalamin is a vitamin of the B-complex family, commonly known as cobalamins (corrinoids). It is a synthetic or man-made form of vitamin B12 that is available as both a prescription and over-the-counter (OTC) medication. Cobalamins exist in several other chemical forms, including hydroxocobalamin, methylcobalamin, and adenosylcobalamin. Cyanocobalamin is the most common form of cobalamins used in nutritional supplements and fortified foods. It contains a cyano (cyanide) group in its structure, which makes it more stable than other forms of vitamin B12 as the cyanide stabilizes the molecule from deterioration. Hydroxocobalamin, however, is the most biologically active form of Vitamin B12; hence, it is more preferable than cyanocobalamin for the treatment of vitamin B12 deficiency.
Cyanocobalamin does not naturally exist in foods owing to the presence of cyanide, which is absent in the natural form of the vitamin. The chemical structure of cyanocobalamin contains the rare mineral cobalt (4.34%), which binds the cyano group and is located in the center of a corrin ring. The commercial manufacturing of the vitamin is done through bacterial fermentation. Compared to other forms of vitamin B12, it is easier to crystallize and more air-stable. Cyanocobalamin is usually obtained as a dark red, amorphous or crystalline powder, orthorhombic needles, or red crystals. The anhydrous form of the compound is highly hygroscopic. It may absorb up to 12% of water if exposed to air. Cyanocobalamin is sparingly soluble in alcohol and water (1 in 80 of water), but insoluble in chloroform, acetone, and ether. The coenzymes of this vitamin are highly unstable in light.
Cyanocobalamin is available in several dosage forms including the tablet, nasal spray, and injection. The US-FDA initially approved the drug in 1942. However, the compound became widely available for routine use in the treatment of B12 deficiency in the early 1950s.
| Pharmacy | ProRX |
|---|---|
| Instructions | Cyanocobalamin vials should be stored at controlled room temperature (15 - 25 °C), protected from excessive light and humidity, and kept in their original packaging to preserve potency; freezing must be avoided to prevent crystal formation and loss of sterility assurance. Refrigeration is not strictly required but may prolong shelf life if temperature excursions are common; when cooled, vials must be allowed to reach ambient temperature before use to minimize syringe air bubble formation and injection discomfort. What items do I need to give a shot?
Syringe Education
How to draw up the medication
Subcutaneous Injections Subcutaneous shots can be given straight in at a 90-degree angle, or at a 45-degree angle. You can give the shot at a 90-degree angle if 2 inches of skin can be grasped between your thumb and first (index) finger. If only 1 inch of skin can be grasped, give the shot at a 45-degree angle
Where can I give a subcutaneous shot? There are many sites on the body that are safe to give Subcutaneous shots.
How do I inject medication into subcutaneous tissue?
Intramuscular Injections How to transfer contents from vial to syringe First, remove the plastic cap from the medication vial and use an alcohol wipe to cleanse the rubber stopper. With a fresh, unused syringe, pull back on the plunger to the amount you are injecting, bringing air into the syringe. Now, remove the plastic cap from the needle. Insert the needle into the vial and slowly push (inject) the air from the syringe into the vial. This will displace the liquid in the vial when you withdraw the medication. Turn the vial and syringe upside down and carefully draw the fluid back into the syringe to the line designating the desired amount of medication. If you see any air bubbles, lightly tap or flick the syringe to draw the bubbles to the top (the end with the needle) and expel the air. Note that a small amount of medication may be released as well. This is normal. You are now ready to inject.
Where can I give an intramuscular shot? The skin and the muscles under the skin cover nerves, blood vessels and bones. It is important to give a shot where you will not hurt any of these body parts. There are 6 possible areas, 3 on each side of the body, where an Intramuscular (IM) shot can be given. It is important to choose the correct area. If caregivers show you what areas are safe, follow their directions. Constantly change the area where you give shots. If you give a shot in the same place every day or even every week, scar tissue can build up. The scar tissue can negatively affect how the medication works. Following this information will help you choose the safest areas to give an intramuscular injection. How do I choose the best muscle for the shot? If your caregivers have told you which muscle to use, follow their directions. Many options change with age. For example, the rear-end area is never used for infants or children under 3-years old because it is not developed well enough. The deltoid may work well for a person with developed muscles in the upper body. The deltoid cannot be used if that area is very thin or underused. The muscles must be easy to reach. How do I inject nutrients into a muscle?
How do I dispose of used syringes and needles? You can purchase a Sharps Container, a hard-plastic container made for used syringes and needles, at your local pharmacy. If you did not purchase this container with your medication, you can use a hard-plastic container with a screw-on top such as a clothing softener or hard plastic detergent bottle. Be sure you can put both the syringe and the needle into the container easily. Whatever container you choose, be sure needles cannot break through the sides, bottom or top. Call your primary care physician or your local pharmacy to find out what your state or local requirements are for disposing of used syringes and needles. |