Melasma HQ 4.1–Hydrocortisone 1%/Hydroquinone 4% / Kojic Acid 4%/Tretinoin 0.1% cream
Hydroquinone 4%/ Tretinoin 0.1%/ Kojic Acid 4%/ Hydrocortisone 1%
Hydroquinone is a topical depigmenting agent. It is structurally related to monobenzone, a potent depigmenting agent. Unlike monobenzone, depigmentation caused by hydroquinone is reversible. Hydroquinone is used for temporary bleaching of hyperpigmented skin conditions such as chloasma (melasma), freckles, and lentigines.
Topical tretinoin is indicated in the treatment of mild to moderate acne (e.g., grades I-III) and photodamaged skin. Topical tretinoin has also been used in the symptomatic management of keratinization disorders such as ichthyosis and keratosis follicularis.
Kojic acid is a chelation agent produced by several species of fungi, especially Aspergillus oryzae, which has the Japanese common name koji. It is a mild inhibitor of the formation of pigment in plant and animal tissues and is used in food and cosmetics to preserve or change colors of substances.
Topical hydrocortisone is considered low potency and is used in mild to moderate corticosteroid-responsive dermatoses, and many topical dosage forms are available without a prescription.