Cystatin C With Glomerular Filtration Rate, Estimated (eGFR) LabCorp

Since it is formed at a constant rate and freely filtered by the healthy kidney, cystatin C is a good marker of renal function. Serum concentrations of cystatin C are almost totally dependent on glomerular filtration rate (GFR). A reduction in GFR causes a rise in the concentration of cystatin C.^1,2

Can be used as a confirmatory test for the diagnosis of chronic kidney disease (CKD) in patients with a decreased GFR as estimated from creatinine.

Data suggests that 3.6% of U.S. adults would be classified as having CKD solely on the basis of a creatinine-based GFR estimate of 45 to 59 mL per minute per 1.73m². A strategy of measuring cystatin C when the creatinine-based estimate is in this range and then reestimating GFR with the use of both these markers could correctly reclassify a substantial proportion of such patients as not having CKD and not being at high risk.

Can also be used to screen for CKD among persons who have a creatinine-based GFR estimate of 60 to 74 mL per minute per 1.73m² without albuminuria (10.9% of US adults) or to obtain a more accurate estimation of GFR in patients with muscle wasting or chronic illness.